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Cymax IL-1α (mouse) ELISA Kit
Product Details | |
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Synonyms | Il1a; IL-1 α; Interleukin-1 α |
Product Type | Kit |
Properties | |
Application Set | Compound Screening |
Crossreactivity | Mouse |
Quantity |
1x96 wells |
Sensitivity | 0.356 pg/ml |
Range | 1.56 pg/ml - 100 pg/ml |
Sample Type |
Buffers Cell Culture Supernatant Cell Lysate Plasma Serum |
Assay Type | Sandwich |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice |
Any unused reconstituted standard should be discarded or frozen at -80℃. Standard can be frozen and thawed one time only without loss of immunoreactivity. |
Documents | |
Manual |
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MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1α and IL-1β. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1α was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1α upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1α is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1α and IL-1β. Although most activators fully rely on the inflammasome for IL-1α secretion, some induce the processing and secretion of IL-1α in an inflammasome-independent manner.