anti-Peroxiredoxin 4, mAb (1A1)

CHF 322.00
In stock
YIF-LF-MA0005100 µlCHF 322.00
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Product Details
Synonyms PRDX4; Prx-IV; AOE37-2; EC=1.11.1.15; Peroxiredoxin-4; Peroxiredoxin IV; Antioxidant Enzyme AOE372; Thioredoxin Peroxidase AO372; Thioredoxin-dependent Peroxide Reductase A0372
Product Type Monoclonal Antibody
Properties
Clone 1A1
Isotype Mouse IgG3 κ
Immunogen/Antigen Recombinant human fragment protein (without secretion leader sequence) purified from E. coli.
Application

Immunoprecipitation (1~2 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 – 30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 6 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol (1). Probably involved in redox regulation of the cell. Regulates the activation of NF-κ-B in the cytosol by a modulation of I-κ-B-α phosphorylation.

Product References

1) Wood, Z. A. et al. (2003) Trends Biochem Sci. 28(1):32-40. (General)

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