anti-PLC γ, mAb (2B1)

CHF 315.00
In stock
YIF-LF-MA0050100 µlCHF 315.00
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Product Details
Synonyms PLC1; PLCG1; PLC-II; PLC-148; EC=; PLC-γ-1; Phospholipase C-II; Phospholipase C-γ-1; Phosphoinositide Phospholipase C-γ-1; 1-Phosphatidylinositol 4;5-Bisphosphate PhosphodiEsterase γ-1
Product Type Monoclonal Antibody
Clone 2B1
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human protein purified from E. coli.

Western Blot (1:2,000)
Immunoprecipitation (1 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG2a Isotype Control

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

The mammalian Phospholipase C (PLC) family has two closely related proteins, PLC1 and PLC2. The PLC isozymes have the core structure domains and a unique array of domains containing an additional PH domain, two SH2 domains and one SH3 domain. In response to extracellular stimuli, such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCγ. Activated PLC catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PLC-γ is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

Product References

1) Katan, M. (1998) Biochim. Biophys. Acta, 1436, 5-17. (General)
2) Singer, W.D. et al. (1997) Annu. Rev. Biochem. 66, 475-509. (General)
3) Wang, Z. et al. (1998) Mol. Cell. Biol. 18, 590-597. (General)

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