anti-Protein Tyrosine Phosphatase 1B, mAb (3A7)

CHF 322.00
In stock
YIF-LF-MA0051100 µlCHF 322.00
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Product Details
Synonyms PTP1B; PTPN1; PTP-1B; EC=3.1.3.48; Protein-Tyrosine Phosphatase 1B; Tyrosine-Protein Phosphatase Non-Receptor Type 1
Product Type Monoclonal Antibody
Properties
Clone 3A7
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

In vivo, tyrosine phosphorylation is reversible and dynamic and the phosphorylation states are governed by the opposing activites of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). PTPs are involved in controlling of diverse array of cellular process. They are large(~100) and structurally diverse family of enzymes. PTPs contain one or two catalytic domains which is approximately 280 residues and are characterized by the existence of the signature motif HC(X)5R. The Cys and Arg residues in this motif have essential functions for catalytic activity. PTPs regulate cell growth and metabolism, with special emphasis on its ability to regulate integrin, growth factor, and cytokine signaling. May play an important role in CKII- and p60c-src-induced signal transduction cascades

Product References

1) Tonks, N.K. (2003) FEBS Lett. 546(1), 140-148. (General)
2) Zhang, Z.Y. (2002) Annu. Rev. Pharmacol. Toxicol. 42, 209-234. (General)
3) Neel, B.G. and Tonks, N.K. (1997) Curr. Opin. Cell. Biol. 9, 193-204. (General)

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