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anti-Selenoprotein M, mAb (10C1)
Product Details | |
---|---|
Synonyms | SEPM; SelM; SELM; Selenoprotein M |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 10C1 |
Isotype | Mouse IgG2a κ |
Immunogen/Antigen | Recombinant human protein purified from E. coli. |
Application |
ELISA |
Crossreactivity | Human |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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A growing body of evidence relates selenium to cancer prevention, immune system function, male fertility, cardiovascular disorder, control of the aging and neurodiseases process. Selenoproteins are thought to be responsible for the majority of these biomedical effects of selenium. Approximately 17 selenoproteins have been identified until now. Although the function of many selenoproteins are unknown, some play important roles in anti-oxidant mechanisms. It has been also implicated in the regulation of signaling pathways through catalysis of thiol/ disulfide exchange. Selenoprotein M(SelM) is especially expressed in a mammalian brain and is localized to the perinuclear structures (Golgi/ER). The roles of selM have not been clearly identified until present time. May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation
1) Korotkov, K.V. et al (2002) Mol.Cell.Biol. 22(5) 1402-1411. (General)
2) Chen, J. and Berry M.J. (2003) J.Neurochem. 86, 1-12. (General)
3) Ganther, H.E. (1999) Carcinogenesis 20(9) 1657-1666. (General)