anti-Amphiphysin, mAb (C14-23)

CHF 322.00
In stock
YIF-LF-MA0063100 µlCHF 322.00
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Product Details
Synonyms AMPH; AMPH1; Amphiphysin
Product Type Monoclonal Antibody
Properties
Clone C14-23
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human GST-fragment protein (320-696AA) purified from E. coli.
Application

Western Blot (1:2,000)
Immunoprecipitation (1~2 μl)
IHC-P (1:100)
ICC (1:100)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome. May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.

Product References

1) Zhang, B. and Zelhof, A.C. (2002) Traffic, 3:452-460. (General)
2) Wigge, P. and McMahon, H.T. (1998) Trends Neurosci. 21, 339-344. (General)
3) Jin, Y., et al (2001) Exp. Mol. Med. 33(2), 69-75. (General)

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