anti-Glutaredoxin 1, mAb (30A1)

CHF 322.00
In stock
YIF-LF-MA0082100 µlCHF 322.00
More Information
Product Details
Synonyms GRX; GLRX; TTase-1; Glutaredoxin-1; Thioltransferase-1
Product Type Monoclonal Antibody
Properties
Clone 30A1
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application

Immunoprecipitation (1~2 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH (1). First recovered in E.coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxido-reductase via two redox-active cysteine residues (2). The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12 kDa dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress (3). Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

Product References

1) Holmgren, A. (1990) p. 146-154, CRC Press Inc., Boca Raton, FL. (General)
2) Holmgren, A. (1989) J. Biol. Chem. 264, 13963-13966. (General)
3) Jung, C. H. and Thomas, J. A. (1996) Arch. Biochem. Biophys. 335, 61-72. (General)

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