anti-Methionine Sulfoxide Reductase A, mAb (1C8)

CHF 322.00
In stock
YIF-LF-MA0083100 µlCHF 322.00
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Product Details
Synonyms MSRA; PMSR; EC=1.8.4.11; Peptide Met(O) Reductase; Protein-Methionine-S-Oxide Reductase; Peptide-Methionine (S)-S-Oxide Reductase, Mitochondrial Peptide Methionine Sulfoxide Reductase
Product Type Monoclonal Antibody
Properties
Clone 1C8
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application

Immunoprecipitation (1~2 μl)

Crossreactivity Human
Mouse
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Methionine sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system. MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin, HIV protease and α1-proteinase-inhibitor (1-3). Recent studies indicate that there is a connection between MsrA and Alzheimer’s disease in mammals (4). Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Product References

1) Sun, H. et al. (1999) Biochemistry. 38, 105-112. (General)
2) Davis, D. A. et al. (2000) Biochem. J. 346, 305-311. (General)
3) Abrams, W. R. et al. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 7483-7486. (General)
4) Gabbita, S. P. et al. (1999) J. Neurochem. 73, 1660-1666. (General)

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