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anti-Glutamine Synthetase, mAb (8G9)
Product Details | |
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Synonyms | GS; GLUL; GLNS; EC=6.3.1.2; EC=4.1.1.15; Glutamine Synthetase; Glutamate Decarboxylase; Glutamate-Ammonia Ligase |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 8G9 |
Isotype | Mouse IgG2a κ |
Immunogen/Antigen | Recombinant human protein purified from E. coli. |
Application |
Immunoprecipitation (1~2 μl) |
Crossreactivity | Human |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Glutamine Synthetase(GS) catalyzes the conversion of ammonia and glutamate to glutamine. This reaction consumes a molecule of ATP: Glutamate + NH4+ + ATP >> Glutamine + ADP + Pi. GS is found in astrocytes as an octamer of identical 45kDa subunits. Most well known function of GS is the detoxification of brain ammonia. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer’s disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. On the other hands, the level of expression of GS is increased during ischemia in vivo or hypoxia in culture. Essential for proliferation of fetal skin fibroblasts.
1) Suárez, I. et al. (2002) Neurochemistry International, 41: 123-142. (General)
2) Kosenko, E. et al (2003) Neurochemistry International, 43: 493-499. (General)