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anti-Paraoxonase 1, mAb (17A12)
Product Details | |
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Synonyms | PON; PON1; K-45; PON 1; EC=3.1.8.1; EC=3.1.1.2; EC=3.1.1.81; A-Esterase 1; Aromatic Esterase 1; Serum Aryldialkylphosphatase 1; Serum Paraoxonase/Arylesterase 1 |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 17A12 |
Isotype | Mouse IgG1 κ |
Immunogen/Antigen | Recombinant human His-PON1 protein purified E. coli. |
Application |
Western Blot (1:500) |
Crossreactivity |
Human Mouse Rat |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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The paraoxonase(PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson’s disease. Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. May mediate an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
1) Akhmedova SN, et al. (2001) J Neurol Sci 184 (2):179-82. (General)
2) Kondo I, et al. (1998) Brain Res 806(2):271-3. (General)