anti-Antithrombin 3, mAb (8C12)

CHF 322.00
In stock
YIF-LF-MA0107100 µlCHF 322.00
More Information
Product Details
Synonyms AT3; ATIII; PRO0309; SERPINC1; Serpin C1; Antithrombin-III
Product Type Monoclonal Antibody
Properties
Clone 8C12
Isotype Mouse IgG1 κ
Immunogen/Antigen Antithrombin III protein purified from human plasma.
Application

ELISA
Western Blot (1:1,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Antithrombin III is a plasma protein synthesized in the liver and has molecular weight of 58kDa. Antithrombin III is a heparin-binding glycoprotein that acts as the major inhibitor of thrombin. Also it interferes with several plasma proteases, including kallikrein and factors IXa, Xa, XIa and XIIa, thereby playing a central role in regulating coagulation. It is also used as a therapeutic agent in patients with sepsis and disseminated intravascular coagulation. In addition, a number of recent studies have shown that antithrombin III has anti-inflammatory properties, which are independent of its effects on coagulation. Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Product References

1) Hajime Saito, et. al (2005) Journal of Leukocyte biology 78, 777-784. (General)

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