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anti-Fibrinogen, mAb (5C5)
Product Details | |
---|---|
Synonyms | FGA; FGB; FGG |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 5C5 |
Isotype | Mouse IgG1 κ |
Immunogen/Antigen | Fibrinogen protein purified from human plasma. |
Application |
ELISA |
Crossreactivity | Human |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Fibrinogen is a soluble glycoprotein found in the plasma, with a molecular weight of 340kDa. It comprises of three pairs of non-identical polypeptide chains (α, 63.5kDa β, 56kDa, and γ, 47kDa chains) linked to each other by disulphide bonds. Low plasma fibrinogen concentrations are therefore associated with an increased risk of bleeding due to impaired primary and secondary hemostasis. Therefore Fibrinogen is an essential component of the blood coagulation system. Also it may play key roles in the process of atherosclerotic lesion formation, with subsequent effects on cardiovascular diseases. And increasing evidence from epidemiological studies suggests that elevated plasma fibrinogen levels are associated with an increased risk of ischaemic heart disease(IHD), stroke and other thromboembolism. Fibrinogen has a double function, yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
1) S. Kamath et al. (2003) Fibrinogen: Biochemistry, epidemiology and determinants. Q J Med 96:711-729. (General)