anti-Fibrinogen, mAb (5C5)

CHF 322.00
In stock
YIF-LF-MA0108100 µlCHF 322.00
More Information
Product Details
Synonyms FGA; FGB; FGG
Product Type Monoclonal Antibody
Properties
Clone 5C5
Isotype Mouse IgG1 κ
Immunogen/Antigen Fibrinogen protein purified from human plasma.
Application

ELISA
Western Blot (1:2,000)
IHC-P
Immunoprecipitation not tested.

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Fibrinogen is a soluble glycoprotein found in the plasma, with a molecular weight of 340kDa. It comprises of three pairs of non-identical polypeptide chains (α, 63.5kDa β, 56kDa, and γ, 47kDa chains) linked to each other by disulphide bonds. Low plasma fibrinogen concentrations are therefore associated with an increased risk of bleeding due to impaired primary and secondary hemostasis. Therefore Fibrinogen is an essential component of the blood coagulation system. Also it may play key roles in the process of atherosclerotic lesion formation, with subsequent effects on cardiovascular diseases. And increasing evidence from epidemiological studies suggests that elevated plasma fibrinogen levels are associated with an increased risk of ischaemic heart disease(IHD), stroke and other thromboembolism. Fibrinogen has a double function, yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Product References

1) S. Kamath et al. (2003) Fibrinogen: Biochemistry, epidemiology and determinants. Q J Med 96:711-729. (General)

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