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anti-Lactoferrin, mAb (1B8)
Product Details | |
---|---|
Synonyms | LTF; GIG12; EC=3.4.21. |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 1B8 |
Isotype | Mouse IgG1 κ |
Immunogen/Antigen | Recombinant human protein purified from E. coli. |
Application |
Immunoprecipitation (1~2 μl) |
Crossreactivity | Human |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Lactoferrin (Lf), one of transferrin family, is found in external fluids, including milk and mucosal secretions, and prominent components of the secondary granules of neutrophils. Lf consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). Lf plays a central role in iron metabolism and host defense system against microbial infection. Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for κ-receptors than for µ-receptors. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity
1) Farnaud, S. and Evans, R.W. (2003) Mol. Immunol. 40, 395-405. (General)
2) Baker, H.M. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 3579-3583. (General)
3) Appelmelk, B.J. et al. (1994) Infect. Immun. 62, 2628-2632. (General)