anti-Glutathione peroxidase 3, mAb (23B1)

CHF 315.00
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YIF-LF-MA0114100 µlCHF 315.00
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Product Details
Synonyms GPXP; GPX3; GPx-P; GPx-3; GSHPx-3; GSHPx-P; EC=; Glutathione Peroxidase 3; Plasma Glutathione Peroxidase; Extracellular Glutathione Peroxidase
Product Type Monoclonal Antibody
Clone 23B1
Isotype Mouse IgG1κ
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Recombinant human Gpx3 fused to a His-tag.
Application Western Blot (2.0 µg/ml)
Crossreactivity Human
Specificity Recognizes human Gpx3.
Purity Protein G purified.
Purity Detail Ammonium sulfate precipitation.
Concentration 2 mg/ml
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Accession Number P22352
Declaration Manufactured by AbFrontier.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/ mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site. Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Product References

1) Takebe, G.. et al. (2002) J. Biol. Chem. 277, 41254-41258. 2) Avissar, N. et al. (1994) Am. J. Physiol. 267, E68-76. 3) Bao, Y. et al. (1997) FEBS Lett. 410, 210-212. 4) Chambers, I. et al. (1986) EMBO J. 5, 1221-1227. 5) Perry, A. et al. (1992) Biochem. J. 285, 863- 870.

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