anti-CDK5, mAb (2G2)

CHF 322.00
In stock
YIF-LF-MA0120100 µlCHF 322.00
More Information
Product Details
Synonyms CDK5; CDKN5; EC=2.7.11.22; TPKII Catalytic Subunit; Cyclin-dependent Kinase 5; Cell Division Protein Kinase 5; Tau Protein Kinase II Catalytic Subunit; Serine/Threonine-Protein Kinase PSSALRE
Product Type Monoclonal Antibody
Properties
Clone 2G2
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-CDK5 protein purified from E. coli.
Application

ELISA
Western Blot (1:1,000~2,000)
Immunoprecipitation (2 μl)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Cyclin-dependent kinase-5 (CDK5) is a member of the cyclin-dependent kinase family of serine/threonine kinases. Its mRNA and protein are expressed in kidney, testes, and ovary. And Its activity is detected almost exclusively in brain extracts. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, Cdk5 activity requires association with one of two brain-specific regulatory subunits called p35 and p39. The two activators regulate the spatial and temporal expression of active Cdk5 to restrict its activity primarily to post-mitotic neurons. Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.

Product References

1) Shirley B. Shelton and Gail V.W. Johnson (2004) Journal of Neurlchemistry 88,1313-1326. (General)
2) Jonathan C Cruz and Li-Huei Tsai (2004) Current Poinion in Neurobiology 14:390-394. (General)
3) Deanna S. Smith, et al. (2001) Cell Growth & Differentiation 12,277-283. (General)

© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.