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anti-Complement Factor H, mAb (34F12)
Product Details | |
---|---|
Synonyms | HF; CFH; H Factor 1; Complement Factor H |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 34F12 |
Isotype | Mouse IgG1 κ |
Immunogen/Antigen | Protein purified from human plasma. |
Application |
ELISA |
Crossreactivity | Human |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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The complement system is a crucial component of the innate immunity against microbial infection. Complement factor H, a 155 kDaplasma glycoprotein, is an essential regulatory protein that plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. Factor H binds to C3b, accelerates the decay of the alternative pathway C3-convertase and acts as a cofactor for the factor I-mediated proteolyticinactivation of C3b. In addition, factor H has multiple physiological activities 1) acts as an extracellularmatrix component, 2) binds to cellular receptors of the integrintype, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin. Complement factor H has revealed an association with two different renal diseases, glomerulonephritisand atypical hemolytic uremicsyndrome (aHUS). Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.
1) Ripoche, J. et al (1988) Biochem J 249: 593-602. (General)
2) Pangburn M. K. et al (2000) J. Immunol. 164: 4742-4751. (General)