anti-PGRP-L, mAb (45G1)
| Product Details | |
|---|---|
| Synonyms | PGRP-L; PGLYRPL; PGLYRP2; EC=3.5.1.28; N-Acetylmuramoyl-L-Alanine Amidase; Peptidoglycan Recognition Protein 2; Peptidoglycan Recognition Protein Long |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 45G1 |
| Isotype | Mouse IgG1 κ |
| Immunogen/Antigen | Peptidoglycan recognition protein (PGRP)-L purified form human protein. |
| Application |
ELISA |
| Crossreactivity | Human |
| Purity Detail | Ammonium sulfate precipitation. |
| Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by AbFrontier |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules that recognize bacteria and their unique cell wall component, peptidoglycan (PGN). Mammals have four PGRPs, designated in humans PGRP-S(24kDa), PGRP-L(60~65kDa), PGRP-Iα(38kDa), and PGRP-Iβ(44kDa). Human PGRPs are differentially expressed in various tissues and organs: PGRP-S mainly in the bone marrow and Polymorphonuclear leukocyte (PMNs), PGRP-L mainly in the liver, and PGRP-Ia and PGRP-Ib mainly in the esophagus. The function of only one mammalian PGRP, PGRP-S, is currently known. Mouse PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein. May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
1) Zheng-Ming Wang et. al. (2003) J Biol Chem 278 (49): 49044-49052. (General)
2) Chao Liu et. al. (2001) J Biol Chem 276(37): 34686-34694. (General)
