anti-PGRP-L, mAb (45G1)

CHF 322.00
In stock
YIF-LF-MA0135100 µlCHF 322.00
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Product Details
Synonyms PGRP-L; PGLYRPL; PGLYRP2; EC=3.5.1.28; N-Acetylmuramoyl-L-Alanine Amidase; Peptidoglycan Recognition Protein 2; Peptidoglycan Recognition Protein Long
Product Type Monoclonal Antibody
Properties
Clone 45G1
Isotype Mouse IgG1 κ
Immunogen/Antigen Peptidoglycan recognition protein (PGRP)-L purified form human protein.
Application

ELISA
Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules that recognize bacteria and their unique cell wall component, peptidoglycan (PGN). Mammals have four PGRPs, designated in humans PGRP-S(24kDa), PGRP-L(60~65kDa), PGRP-Iα(38kDa), and PGRP-Iβ(44kDa). Human PGRPs are differentially expressed in various tissues and organs: PGRP-S mainly in the bone marrow and Polymorphonuclear leukocyte (PMNs), PGRP-L mainly in the liver, and PGRP-Ia and PGRP-Ib mainly in the esophagus. The function of only one mammalian PGRP, PGRP-S, is currently known. Mouse PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein. May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.

Product References

1) Zheng-Ming Wang et. al. (2003) J Biol Chem 278 (49): 49044-49052. (General)
2) Chao Liu et. al. (2001) J Biol Chem 276(37): 34686-34694. (General)

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