anti-Glutathione Peroxidase 3, mAb (55A)
Product Details | |
---|---|
Synonyms | GPXP; GPX3; GPx-P; GPx-3; GSHPx-3; GSHPx-P; EC=1.11.1.9; Glutathione Peroxidase 3; Plasma Glutathione Peroxidase; Extracellular Glutathione Peroxidase |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 55A |
Isotype | Mouse IgG2b κ |
Immunogen/Antigen | Recombinant human protein purified from E. coli. |
Application |
ELISA |
Crossreactivity | Human |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | No |
Product Specification Sheet | |
Datasheet |
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Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic /mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract (1). Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation (2). Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine (3). All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site (4-5). Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
1) Takebe, G.. et al. (2002) J. Biol. Chem. 277, 41254-41258. (General)
2) Avissar, N. et al. (1994) Am. J. Physiol. 267, E68-76. (General)
3) Bao, Y. et al. (1997) FEBS Lett. 410, 210-212. (General)
4) Chambers, I. et al. (1986) EMBO J. 5, 1221-1227. (General)
5) Perry, A. et al. (1992) Biochem. J. 285, 863-870. (General)