anti-Attractin, mAb (9H8)

CHF 322.00
In stock
YIF-LF-MA0146100 µlCHF 322.00
More Information
Product Details
Synonyms ATRN; DPPT-L; KIAA0548; Attractin; Mahogany Homolog
Product Type Monoclonal Antibody
Properties
Clone 9H8
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

Western Blot (1:1,000)
Immunoprecipitation (1~2 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Attractin is a serum glycoprotein of 175 kDa and found in both membrane-bound and secreted forms as a result of alternative splicing. Both the secreted and membrane-bound forms of attractin may be involved in the development and maintenance of the central nervous system. Membrane-bound attractin is a co-receptor for Agouti, antagonist of melanocortin-1 receptor. Secreted attractin, expressed by activated T lymphocytes and modulates interactions between T cells and monocytes/macrophages, was examined as a potential marker of immune activity. Attractin may be a component of a pathway for regulated protein turnover that also involves mahogunin, a wide-expressed E3 ubiquitin ligase found at particularly high levels in the brain. Attractin was considered as an extracellular target amenable for the development of obesity-regulating drugs, also. Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system

Product References

1) Duke-Cohan, J. S., et al, PNAS (1998), vol.95 (19): pp.11336~11341. (General)
2) He, L., et al, Nature Genetics (2001) vol.27: pp.40~47. (General)
3) Duke-Cohan, J. S., et al, J Environ Pathol Toxicol Oncol. (2004) vol. 23: pp.1~11. (General)

© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.