anti-Inter-α-Trypsin Inhibitor, mAb (40B10)

CHF 322.00
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YIF-LF-MA0148100 µlCHF 322.00
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Product Details
Synonyms SHAP; ITIH1; IGHEP1; ITI-HC1; ITI Heavy Chain H1; Inter-α-Inhibitor Heavy Chain 1; Serum-derived Hyaluronan-associated Protein; Inter-α-Trypsin Inhibitor Heavy Chain H1
Product Type Monoclonal Antibody
Properties
Clone 40B10
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

Western Blot (1:500~1,000)
IHC-P

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

The inter-α-trypsin inhibitor (ITI, IαI) family, a typical and classical example for protein-glycosaminoglycan-protein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology. May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.

Product References

1) Cuvelier A. et al, Rev Mal Respir. (2000) vol.17(2): pp.437~446. (General)
2) Zhuo L. et al, J. Biol. Chem., (2004) vol.279(37): pp.38079~38082. (General)
3) Tamra, E. et al, Cancer Res., (2006) vol.66(3): pp.1464~1472. (General)
4) Salier J.P. et al, Biochem J. (1996) vol.315 (Pt 1) : pp.1~9. (General)

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