anti-Complement Factor H, mAb (63G5)

CHF 322.00
In stock
YIF-LF-MA0149100 µlCHF 322.00
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Product Details
Synonyms HF; CFH; H Factor 1; Complement Factor H
Product Type Monoclonal Antibody
Clone 63G5
Isotype Mouse IgG2b κ
Immunogen/Antigen Protein purified from human plasma.
Application ELISA
Immunoprecipitation (1 μl)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Product Specification Sheet
Datasheet Download PDF
The complement system is a crucial component of the innate immunity against microbial infection. Complement factor H, a 155 kDa plasma glycoprotein, is an essential regulatory protein that plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. Factor H binds to C3b, accelerates the decay of the alternative pathway C3-convertase and acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b. In addition, factor H has multiple physiological activities 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin. Complement factor H has revealed an association with two different renal diseases, glomerulonephritis and atypical hemolytic uremic syndrome (aHUS). Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.
Product References
1) Ripoche, J. et al (1988) Biochem J 249: 593-602. (General)
2) Pangburn M. K. et al (2000) J. Immunol. 164: 4742-4751. (General)
3) Rodriguez de Cordoba S, et al, (2004) Mol Immunol. vol.41(4): pp.355-67. (General)
4) Zipfel PF. (2001) Semin Thromb Hemost. vol.27(3): pp.191-9. (General)
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