anti-MPO (Myeloperoxidase), mAb (1A1)

CHF 322.00
In stock
YIF-LF-MA0154100 µlCHF 322.00
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Product Details
Synonyms MPO; EC=1.11.2.2
Product Type Monoclonal Antibody
Properties
Clone 1A1
Isotype Mouse IgG1 κ
Immunogen/Antigen Purified from human sputum.
Application

ELISA
Immunoprecipitation (2 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Myeloperoxidase is a major neutrophil protein and is also present in monocytes. In neutrophils, it is stored in azurophilic granules and released during phagocytosis. It is a heme enzyme that uses the superoxide and hydrogen peroxide generated by the neutrophil oxidative burst to produce hypochlorous acid and other reactive oxidants.The produced hypochlorous acid reacts with and destroys bacteria. In many inflammatory pathologies, such as cystic fibrosis and rheumatoid arthritis, neutrophils are also causing tissue damage. MPO is thought to be the most promising cardiac marker at the moment. In addition to that MPO is a good inflammatory biomarker for autoimmune, inflammatory diseases and cancer. Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Product References

1) Winterbourn CC, et al, Curr Opin Hematol. (2000) vol.7(1): pp.53-8. (General)
2) Hansson M, et al, Arch Biochem Biophys. (2006) vol.445(2): pp.214-24. (General)
3) Nicholls SJ, Hazen SL. Arterioscler Thromb Vasc Biol. (2005) vol.25(6): pp.1102-11. (General)
4) Klebanoff SJ. J Leukoc Biol. (2005) vol.77(5): pp.598-625. (General)

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