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anti-CDK6, mAb (75B9)
Product Details | |
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Synonyms | CDK6; CDKN6; EC=2.7.11.22; Cyclin-dependent Kinase 6; Cell Division Protein Kinase 6; Serine/Threonine-Protein Kinase PLSTIRE |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 75B9 |
Isotype | Mouse IgG2b κ |
Immunogen/Antigen | Recombinant human protein purified from E. coli. |
Application |
ELISA |
Crossreactivity | Human |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Cyclin-dependent kinase 6 (CDK6) is a 40 kDa member of the CDK family of mitotic kinases involved in cell cycle progression. CDKs are the catalytic subunits of the cyclin/CDK complexes, which phosphorylate substrates on threonine/serine residues. CDK6 associates with the D-type cyclins and is important in the progression of cells from the G1-phase to the S-phase of the cell cycle. Loss of normal cell cycle regulation is the hallmark of human cancers, and alteration of the components involved in cell cycle regulation occurs in most human tumors. This suggests that CDK6 is an attractive target for the development of pharmacological agents for the treatment of cancer. Recently, several studies have indicated a novel role for cdk6 in differentiation, also. Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.
1) Grossel MJ, Hinds PW, J Cell Biochem. (2006) vol.97(3): pp.485-93. (General)
2) Grossel MJ, Hinds PW, Cell Cycle. (2006) vol.5(3): pp.266-70. (General)
3) Hirai H et al, Curr Top Med Chem. (2005) vol.5(2): pp.167-79. (General)