anti-CDK6, mAb (75B9)

CHF 315.00
In stock
YIF-LF-MA0155100 µlCHF 315.00
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Product Details
Synonyms CDK6; CDKN6; EC=; Cyclin-dependent Kinase 6; Cell Division Protein Kinase 6; Serine/Threonine-Protein Kinase PLSTIRE
Product Type Monoclonal Antibody
Clone 75B9
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human protein purified from E. coli.

Western Blot (1:500)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG2b Isotype Control

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Cyclin-dependent kinase 6 (CDK6) is a 40 kDa member of the CDK family of mitotic kinases involved in cell cycle progression. CDKs are the catalytic subunits of the cyclin/CDK complexes, which phosphorylate substrates on threonine/serine residues. CDK6 associates with the D-type cyclins and is important in the progression of cells from the G1-phase to the S-phase of the cell cycle. Loss of normal cell cycle regulation is the hallmark of human cancers, and alteration of the components involved in cell cycle regulation occurs in most human tumors. This suggests that CDK6 is an attractive target for the development of pharmacological agents for the treatment of cancer. Recently, several studies have indicated a novel role for cdk6 in differentiation, also. Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.

Product References

1) Grossel MJ, Hinds PW, J Cell Biochem. (2006) vol.97(3): pp.485-93. (General)
2) Grossel MJ, Hinds PW, Cell Cycle. (2006) vol.5(3): pp.266-70. (General)
3) Hirai H et al, Curr Top Med Chem. (2005) vol.5(2): pp.167-79. (General)

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