anti-IKK-α (3A11)

CHF 322.00
In stock
YIF-LF-MA0161100 µlCHF 322.00
More Information
Product Details
Synonyms IKKA; CHUK; IKK1; IkBKA; IKK-A; TCF-16; NFKBIKA; IKK-α; EC=2.7.11.10; IκB Kinase; I-κ-B Kinase 1; I-κ-B Kinase α; Transcription Factor 16
Product Type Monoclonal Antibody
Properties
Clone 3A11
Isotype Mouse IgG1 κ
Immunogen/Antigen Synthetic peptide.
Application

Western Blot (1:1,000)
Immunoprecipitation (1 μl)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

IκB kinase α (IKKα) is a component of a multiprotein kinase complex that regulates the activity of the transcription factor NF-κB. Activation of the IKK complex via upstream stimuli leads to phosphorylation and degradation of NF-κB bound IκB(Inhibitor of κB). Subsequently, free NF-κB dimers enter the nucleus and regulate the transcription of a variety of target genes involved in cell proliferation and differentiation, apoptosis, and inflammation, etc. The IKK complex consists of 2 highly homologous kinase subunits, IKKα and IKKβ, and a nonenzymatic regulatory component, IKKγ/NEMO. The relative contributions of IKKα and IKKβ to the signalling complex vary according to the requirements of the cell. IKKβ plays a predominant role in immune responses, while IKKα alone appears to be sufficient for at least some developmental systems. Recently, IKK/NF-κB signaling pathway was studied as therapeutic targets in cancer. Acts as part of the IKK complex in the conventional pathway of NF-κ-B activation and phosphorylates inhibitors of NF-κ-B thus leading to the dissociation of the inhibitor/NF-κ-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-κ-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-κ-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-κ-B-regulated promoters during inflammatory responses triggered by cytokines.

Product References

1) Luo JL et al, J Clin Invest. (2005) vol.115(10): pp.2625-32. (General)
2) DiDonato JA. Sci STKE. (2001) vol.2001(97): pp.PE1. (General)
3) Clarkson R. Breast Cancer Res. (2002) vol.4(5): pp.173–5. (General)
4) Kim HJ, et al, Cell Death Differ. (2006) vol.13(5): pp.738-47. (General)

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