anti-Retinol Binding Protein (20F9)

CHF 322.00
In stock
YIF-LF-MA0162100 µlCHF 322.00
More Information
Product Details
Synonyms RBP4; PRO2222
Product Type Monoclonal Antibody
Properties
Clone 20F9
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

ELISA
Western Blot (1:1,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Retinol binding protein (RBP), a 21kDa single-chain glycoprotein, is the primary plasma transport protein for retinol (vitamin A1). RBP solubilizes the water-insoluble retinol and works as a vehicle for transport to the target organs, and it may also protect the bound retinol from oxidative damage in the plasma. The circulating RBP binds to another protein called transthyretin (TTR), a 55-kDa plasma thyroxine binding protein. Such protein-protein complex formation is thought to prevent glomerular filtration of low molecular mass RBP. Serum levels of RBP are useful in the detection of liver disease, protein-calorie malnutrition, and vitamin A deficiencies. In addition, the determination of RBP serum levels has been shown to be important in the mediation of antitumor effects. Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

Product References

1) Zanotti G, Berni R. Vitam Horm. (2004) vol.69: pp.271-95. (General)
2) Newcomer ME, Ong DE. Biochim Biophys Acta. (2000) vol.1482: pp.57-64. (General)
3) Raghu P, Sivakumar B. Biochim Biophys Acta. (2004) vol.1703: pp.1-9. (General)

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