anti-IgG (human) (3E8)

CHF 322.00
In stock
YIF-LF-MA0163100 µlCHF 322.00
More Information
Product Details
Synonyms IGHG1; Ig γ-1 Chain C Region
Product Type Monoclonal Antibody
Properties
Clone 3E8
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

ELISA
Western Blot (1:2,000)
Immunoprecipitation (0.5 μl)
IHC-P

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Immunoglobulin G (IgG) is a monomeric immunoglobulin, built of two heavy chains γ and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids. This is the only isotype that can pass through the placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%). 1) IgG1, IgG3 and IgG4 cross the placenta easily. 2) IgG3 is the most effective complement activator and IgG4 does not activate complement. 3) IgG1 and IgG3 bind with high affinity to Fc receptors on phagocytic cells. IgG4 has intermediate affinity and IgG2 affinity is extremely low.

Product References

1) Grubb R. Exp Clin Immunogenet. (1995) vol.12(3): pp.191-7. (General)
2) Stewart AK, Schwartz RS. Blood. (1994) vol.83(7): pp.1717-30. (General)

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