anti-IgA (human) (47C12)

CHF 322.00
In stock
YIF-LF-MA0165100 µlCHF 322.00
More Information
Product Details
Synonyms IGHA2; Ig α-2 Chain C Region
Product Type Monoclonal Antibody
Properties
Clone 47C12
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

ELISA
Western Blot (1:2,000)
Immunoprecipitation (0.5 μl)
IHC-P

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

IgA represents about 15% to 20% of immunoglobulins in the blood, although it is primarily secreted across the mucosal tract into the stomach and intestines. This prevents microbes from binding to epithelial cells in the digestive and respiratory tracts. It does not activate complement, and opsonises only weakly. It exists in two forms, IgA1 (90%) and IgA2 (10%) that differ in the structure. IgA1 is composed like other proteins, however in IgA2 the heavy and light chains are not linked with disulfide but with noncovalent bonds. IgA1 is found in serum and made by bone marrow B cells, however IgA2 is made by B cells located in the mucosae and has been found to secrete into, colostrum, maternal milk, tears and saliva. The IgA found in secretions represent dimeric form, linked by two additional chains, the J chain and the secretory chain. Decreased or absent IgA, termed selective IgA deficiency, can be a clinically significant immunodeficiency. Igα is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

Product References

1) Grubb R. Exp Clin Immunogenet. (1995) vol.12(3): pp.191-7. (General)
2) Stewart AK, Schwartz RS. Blood. (1994) vol.83(7): pp.1717-30. (General)

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