anti-α1-Antichymotrypsin (71A1)

CHF 322.00
In stock
YIF-LF-MA0166100 µlCHF 322.00
More Information
Product Details
Synonyms AACT; GIG24; SERPINA3
Product Type Monoclonal Antibody
Properties
Clone 71A1
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

Western Blot (1:1,000)
IHC-P

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

α-1-antichymotrypsin (ACT) is a glycoprotein with a molecular weight of 55~68 kDa and 25% by weight of various sugars, whose heterogeneity results in variation of molecular weight. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. Plasma ACT levels might increase rapidly more than 5-fold during an acute phase reaction, ACT has been shown to promote Aβ polymerization in vitro and in vivo, and levels of ACT protein in plasma and cerebrospinal fluid from Alzheimer's patients have been found to correlate with progression of dementia. Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.

Product References

1) Zhang S, Janciauskiene S. J Alzheimers Dis. (2002) vol.4(2): pp.115-22. (General)
2) J, Levy M, Dickson DW, Brain. (2006) vol.129(Pt 11) : pp.3020-34. (General)

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