anti-Complement Factor B, mAb (28A3)

CHF 322.00
In stock
YIF-LF-MA0169100 µlCHF 322.00
More Information
Product Details
Synonyms BF; CFB; EC=3.4.21.47
Product Type Monoclonal Antibody
Properties
Clone 28A3
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

ELISA
Western Blot (1:1,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Complement factor B, a 93kDa glycoprotein, is a component of the alternative complement pathway. Complement factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. The alternative pathway is associated with inflammation, immunologic regulation, and bacterial cytotoxicity. In addition to its roles in the activation of the alternative pathway and enhancing bacterial phagocytosis by macrophages, Complement factor B may also play a role in B cell proliferation, monocyte cytotoxicity, macrophage spreading, immunosuppression, and apoptosis. Complement factor B has been shown to be involved in many diseases such as septic shock, stroke, systemic lupus erythematosus, Alzheimer’s disease, and multiple sclerosis. Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Product References

1) Huang Y, et al, J Immunol. (2002) vol.169(5): pp.2627-35. (General)
2) Hourcade DE, et al, J Biol Chem. (1998) vol.273(40): pp.25996-6000. (General)
3) Xu Y, et al, J Biol Chem. (2000) vol.275(1): pp.378-85. (General)

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