anti-Prothrombin Precursor, mAb (28H5)

CHF 315.00
In stock
YIF-LF-MA0171100 µlCHF 315.00
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Product Details
Synonyms F2; EC=
Product Type Monoclonal Antibody
Clone 28H5
Isotype Mouse IgG2b κ
Immunogen/Antigen Protein purified from human plasma.

Western Blot (1:1,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG2b Isotype Control

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Prothrombin precursor is synthesized in liver as a precursor of prothrombin containing a signal sequence and a propeptide domain at the N-terminus. Before its secretion into plasma, this precursor undergoes several posttranslational modifications, including removal of signal sequence and propeptide domains, glycosylation, and γ-glutamyl-carboxylation reaction. Prothrombin, cleaved by the prothrombinase enzyme complex that consists of serine protease factor Xa, cofactor Va, phospholipids and calcium, is converted to thrombin which converts fibrinogen into fibrin which in turn strengthens a protective clot. Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin(e.g. hypoprothrombinemia) have been described. Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

Product References

1) Zhang P, Suttie JW, Blood (1994) vol.84: 169-75. (General)
2) Taylor R, Wallin R, Biochem J. (1991) vol.277(Pt 1) : pp.59–65. (General)
3) J W Suttie, et al, Proc Natl Acad Sci U S A. (1987) vol.84(3): pp.634–7. (General)

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