anti-α1-Antitrypsin, mAb (48D2)

CHF 322.00
In stock
YIF-LF-MA0175100 µlCHF 322.00
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Product Details
Synonyms AAT; PRO0684; SERPINA1
Product Type Monoclonal Antibody
Properties
Clone 48D2
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

Western Blot (1:4,000)
IHC-P

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

α1-antitrypsin, 52kDa, is the prototypic member of the serine protease inhibitor (serpin) superfamily, which have a major role in inactivating neutrophil elastase and other proteases to maintain protease-antiprotease balance. The protein is synthesized mainly in the liver, but exerts its main function in the lung where it inhibits a variety of serine proteases, but primarily neutrophil elastase. It provides more than 90% of the antiproteolytic shield of the lower respiratory tract protecting the elastic tissue from degradation. Disorders of the enzyme include α 1-antitrypsin deficiency, a hereditary disorder in which lack of α 1-antitrypsin leads to uninhibited tissue breakdown during inflammation. This causes pulmonary emphysema and leads to liver cirrhosis in severe cases. Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Short peptide from AAT (SPAAT) is a reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

Product References

1) Abusriwil H, Stockley RA. Curr Opin Pulm Med. (2006) vol.12(2): p.125-31. (General)
2) Stoller JK, Aboussouan LS. Lancet. (2005) vol.365(9478): p.2225-36. (General)
3) Ranes J, Stoller JK. Semin Respir Crit Care Med. (2005) vol.26(2): p.154-66. (General)
4) Brantly M. Am J Respir Cell Mol Biol. (2002) vol.27(6): p.652-4. (General)

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