anti-Gelsolin, mAb (35B2)

CHF 315.00
In stock
YIF-LF-MA0176100 µlCHF 315.00
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Product Details
Synonyms GSN; ADF; AGEL; Brevin; Gelsolin; Actin-depolymerizing Factor
Product Type Monoclonal Antibody
Clone 35B2
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.

Western Blot (1:2,000)
Immunoprecipitation (0.5 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Gelsolin superfamily proteins control actin organization by severing filaments, capping filament ends and nucleating actin assembly. Gelsolin, a protein of 82–84 kDa, is the founding member of this family, which now contains at least another six members: villin, adseverin, capG, advillin, supervillin and flightless I. Gelsolin exists as a cytoplasmic as well as a plasma isoform, and can bind, sever and cap actin filaments. Plasma gelsolin level decreases dramatically as a result of major trauma and reinfusion of gelsolin can protect against lung damage associated with major burn injury and other types of insults. Recent study in Fas antibody-induced liver failure suggests that gelsolin exerts an overall anti-apoptotic effect in vivo. Gelsolin, a marker of motility, could be applied as a biomarker in assessing tumor prognosis. Tumor-associated processes such as invasion and metastasis are known to be critically dependent on dynamic alterations in the organization of the actin cytoskeleton. A causal relationship between gelsolin expression and in vitro invasion by way of signaling through Ras has been reported. Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.

Product References

1) Leifeld, L. et al., (2006) Am J Pathol.168:778-785. (General)
2) Yang, J. et al., (2006) BMC Cancer. 6:203. (General)
3) Silacci, P. et al., (2004) Cell Mol Life Sci. 61:2614-2623. (General)
4) Christofidou-Solomidou M. et al., (2002) Lung 180: 91–104. (General)
5) De Corte, V. t al., (2002) EMBO J. 21:6781-6790. (General)

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