anti-Gelsolin, mAb (35B2)

CHF 322.00
In stock
YIF-LF-MA0176100 µlCHF 322.00
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Product Details
Synonyms GSN; ADF; AGEL; Brevin; Gelsolin; Actin-depolymerizing Factor
Product Type Monoclonal Antibody
Properties
Clone 35B2
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

Western Blot (1:2,000)
Immunoprecipitation (0.5 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Gelsolin superfamily proteins control actin organization by severing filaments, capping filament ends and nucleating actin assembly. Gelsolin, a protein of 82–84 kDa, is the founding member of this family, which now contains at least another six members: villin, adseverin, capG, advillin, supervillin and flightless I. Gelsolin exists as a cytoplasmic as well as a plasma isoform, and can bind, sever and cap actin filaments. Plasma gelsolin level decreases dramatically as a result of major trauma and reinfusion of gelsolin can protect against lung damage associated with major burn injury and other types of insults. Recent study in Fas antibody-induced liver failure suggests that gelsolin exerts an overall anti-apoptotic effect in vivo. Gelsolin, a marker of motility, could be applied as a biomarker in assessing tumor prognosis. Tumor-associated processes such as invasion and metastasis are known to be critically dependent on dynamic alterations in the organization of the actin cytoskeleton. A causal relationship between gelsolin expression and in vitro invasion by way of signaling through Ras has been reported. Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.

Product References

1) Leifeld, L. et al., (2006) Am J Pathol.168:778-785. (General)
2) Yang, J. et al., (2006) BMC Cancer. 6:203. (General)
3) Silacci, P. et al., (2004) Cell Mol Life Sci. 61:2614-2623. (General)
4) Christofidou-Solomidou M. et al., (2002) Lung 180: 91–104. (General)
5) De Corte, V. t al., (2002) EMBO J. 21:6781-6790. (General)

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