anti-Erk2, mAb (1A8)

CHF 322.00
In stock
YIF-LF-MA0179100 µlCHF 322.00
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Product Details
Synonyms ERT1; ERK2; MAPK1; ERK-2; MAPK 2; MAPK 1; p42-MAPK; EC=; MAP Kinase 1; MAP Kinase 2; MAP Kinase Isoform p42; Mitogen-activated Protein Kinase 1; Mitogen-activated Protein Kinase 2
Product Type Monoclonal Antibody
Clone 1A8
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-Erk2 protein purified from E. coli.
Application ELISA
Western Blot (1:1,000)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Product Specification Sheet
Datasheet Download PDF
ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase, and activates it as well. Once actived, Raf phosphorylates the other two kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in ERK 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1. Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4 (HSF4).
Product References
1) Smalley, K. (2003) Int. J. Cancer, 104, 527-532. (General)
2) Johnson, G.L. and Lapadat, R. (2002) Science, 298, 1911-1912. (General)
3) Kolch, W. (2000) Biochem. J. 351, 289-305. (General)
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