anti-ITI H4, mAb (45A12)

CHF 322.00
In stock
YIF-LF-MA0180100 µlCHF 322.00
More Information
Product Details
Synonyms IHRP; ITIH4; PRO1851
Product Type Monoclonal Antibody
Properties
Clone 45A12
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

ELISA
Western Blot (1:2,000)
IHC-P

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

The inter-α-trypsin inhibitor (ITI, IαI) family, a typical and classical example for protein-glycosaminoglycanprotein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family, it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology. May be involved in acute phase reactions.

Product References

1) Tamra, E. et al., 2006, Cancer Res. 66:1464-1472. (General)
2) Zhuo, L. et al., 2004, J. Biol. Chem. 279:38079-38082. (General)
3) Cuvelier, A. et al., 2000, Rev Mal Respir. 17:437-446. (General)
4) Salier, J.P. et al., 1996, Biochem J. 315(Pt 1) :1-9. (General)

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