Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
anti-Complement Factor C8 β Propeptide, mAb (14A10)
Product Details | |
---|---|
Synonyms | C8B; Complement Component C8 β Chain; Complement Component 8 Subunit β |
Product Type | Monoclonal Antibody |
Properties | |
Clone | 14A10 |
Isotype | Mouse IgG1 κ |
Immunogen/Antigen | Protein purified from human plasma. |
Application |
ELISA |
Crossreactivity | Human |
Purity Detail | Ammonium sulfate precipitation. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Isotype Negative Control | |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
![]() |
The complement system is a part of the larger immune system and three biochemical pathways are present: the classical complement pathway, the alternative pathway, and the mannose-binding lectin pathway. Human complement factor C8 is one of five components (C5b, C6, C7, C8, and C9) that interact to form the cytolytic membrane attack complex (MAC) which is the cytolytic end product of the complement cascade. MAC is typically formed on the surface of intruding pathogenic bacterial as a result of the activation of the complement system, and it is one of the ultimate weapons of the immune system. C8 is composed of an α (64 kDa), β (64 kDa), and γ (22 kDa) subunit. Within C8, the subunits are arranged as a disulfide-linked C8 α-γ heterodimer that is noncovalently associated with C8 β. During MAC formation, C8 α mediates binding and self-polymerization of C9 to form a pore-like structure on the membrane of target cells. Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
1) Scibek, J.J. et al., (2002) Biochemistry. 41:14546-14551. (General)
2) Esser, A. F., (1994) Toxicology 87:229-247. (General)
3) Muller-Eberhard, H. J., (1988) Annu. ReV. Biochem. 57:321-347. (General)