anti-RSK1 (p90RSK1), mAb (8C12)

CHF 315.00
In stock
YIF-LF-MA0183100 µlCHF 315.00
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Product Details
Synonyms RSK-1; p90S6K; p90RSK1; RPS6KA1; p90-RSK 1; MAPKAPK1A; MAPKAPK-1a; EC=; S6K-α-1; MAPKAP Kinase 1a; Ribosomal S6 Kinase 1; MAPK-activated Protein Kinase 1a
Product Type Monoclonal Antibody
Clone 8C12
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-RSK1 protein purified from E. coli.

Western Blot (1:2,000)
Immunoprecipitation (0.5 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threon-ine kinases that lie at the terminus of the ERK pathway. In humans, the RSK family consists of four isoforms (RSK1 to -4). RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, both of which are catalytically functional. Theses kinase dimains are activated in a sequential manner by a series of phosphorylations. RSK regulates gene expression via association and phosphor-ylation of transcriptional regulators includ-ing c-Fos, estrogen receptor, NFκB/IκB α, cAMP-response element-binding protein (CREB). Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

Product References

1) Roux, P. P. et al., (2003) Mol Cell Biol. 23: 4796–4804. (General)
2) Frodin, M. and Gammeltoft ,S., (1999) Mol Cell Endocrinol. 151:65-77. (General)
3) Fisher, T. L. and Blenis, J., (1996) Mol. Cell. Biol. 16:1212-1219. (General)

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