anti-RSK1 (p90RSK1), mAb (8C12)

CHF 322.00
In stock
YIF-LF-MA0183100 µlCHF 322.00
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Product Details
Synonyms RSK-1; p90S6K; p90RSK1; RPS6KA1; p90-RSK 1; MAPKAPK1A; MAPKAPK-1a; EC=; S6K-α-1; MAPKAP Kinase 1a; Ribosomal S6 Kinase 1; MAPK-activated Protein Kinase 1a
Product Type Monoclonal Antibody
Clone 8C12
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-RSK1 protein purified from E. coli.
Application ELISA
Western Blot (1:2,000)
Immunoprecipitation (0.5 μl)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Product Specification Sheet
Datasheet Download PDF
The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threon-ine kinases that lie at the terminus of the ERK pathway. In humans, the RSK family consists of four isoforms (RSK1 to -4). RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, both of which are catalytically functional. Theses kinase dimains are activated in a sequential manner by a series of phosphorylations. RSK regulates gene expression via association and phosphor-ylation of transcriptional regulators includ-ing c-Fos, estrogen receptor, NFκB/IκB α, cAMP-response element-binding protein (CREB). Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
Product References
1) Roux, P. P. et al., (2003) Mol Cell Biol. 23: 4796–4804. (General)
2) Frodin, M. and Gammeltoft ,S., (1999) Mol Cell Endocrinol. 151:65-77. (General)
3) Fisher, T. L. and Blenis, J., (1996) Mol. Cell. Biol. 16:1212-1219. (General)
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