anti-Hairy and Enhancer of Split 1 (HES), mAb (7H11)

CHF 322.00
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YIF-LF-MA0184100 µlCHF 322.00
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Product Details
Synonyms hHL; HES1; BHLHB39; bHLHb39; Hairy Homolog; Hairy-like Protein; Transcription Factor HES-1; Hairy and Enhancer of Split 1; Class B Basic Helix-Loop-Helix Protein 39
Product Type Monoclonal Antibody
Properties
Clone 7H11
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His-Hes1 protein purified from E. coli.
Application

ELISA
Western Blot (1:500~1,000)
Immunoprecipitation (1 μl)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and β-cells. Recent integrative genomic analyses on HES/HEY family suggest that HES1 and HES3 are target genes of the embryonic stem cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL are target genes of Notch signaling pathway.

Product References

1) Kato, M. and Kato, M., (2007) Int J Oncol. 31:461-466. (General)
2) Abderrahmani, A. et al., (2005) FEBS Lett. 579:6199-6204. (General)
3) Iso, T. et al., (2003) J Cell Physiol. 194:237-255. (General)

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