anti-IKK β, mAb (42D1)

CHF 315.00
In stock
YIF-LF-MA0192100 µlCHF 315.00
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Product Details
Synonyms IKKB; IKK2; IKBKB; IkBKB; IKK-B; NFKBIKB; IKK-β; EC=; I-κ-B Kinase 2; I-κ-B-Kinase β; Nuclear Factor NF-κ-B Inhibitor Kinase β
Product Type Monoclonal Antibody
Clone 42D1
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His-IKKβ protein purified from E. coli.

Western Blot (1:5,000)
Immunoprecipitation (2 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG2b Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

IκB kinase β (IKKβ) is a component of a multiprotein kinase complex that regulates the activity of the transcription factor NF-κB. Activation of the IKK complex via upstream stimuli leads to phosphorylation and degradation of NF-κB bound IκB (Inhibitor of κB). Subsequently, free NF-κB dimers enter the nucleus and regulate the transcription of a variety of target genes involved in cell proliferation and differentiation, apoptosis, and inflammation, etc. The IKK complex consists of 2 highly homologous kinase subunits, IKKα and IKKβ, and a nonenzymatic regulatory component, IKKγ/NEMO. The relative contributions of IKKα and IKKβ to the signaling complex vary according to the requirements of the cell. IKKβ plays a predominant role in immune responses, while IKKα alone appears to be sufficient for at least some developmental systems. Recently, IKK/NF-κB signaling pathway was studied as therapeutic targets in cancer. Acts as part of the IKK complex in the conventional pathway of NF-κ-B activation and phosphorylates inhibitors of NF-κ-B thus leading to the dissociation of the inhibitor/NF-κ-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.

Product References

1) Luo JL et al, J Clin Invest. (2005) vol.115(10): pp.2625-32. (General)
2) DiDonato JA. Sci STKE. (2001) vol.2001(97): pp.PE1. (General)
3) Clarkson R. Breast Cancer Res. (2002) vol.4(5): pp.173–5. (General)
4) Kim HJ, et al, Cell Death Differ. (2006) vol.13(5): pp.738-47. (General)

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