anti-PRAK, mAb (13H5)

CHF 315.00
In stock
YIF-LF-MA0195100 µlCHF 315.00
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Product Details
Synonyms MK5; MK-5; PRAK; MAPKAPK5; MAPKAP-K5; MAPKAPK-5; EC=; MAPKAP Kinase 5; MAPK-activated Protein Kinase 5; MAP Kinase-activated Protein Kinase 5; p38-regulated/activated Protein Kinase
Product Type Monoclonal Antibody
Clone 13H5
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-PRAK protein purified from E. coli.

Western Blot (1:5,000~10,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

PRAK is a 471 amino acid protein with 20-30% sequence identity to the known MAP kinase-regulated protein kinases RSK1/2/3, MNK1/2 and MAPKAPK2/3. The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. There are at least six protein kinases that can be regulated by p38α and/or p38β. These downstream kinases of p38s include MAPK-activated protein kinase 2 (MAPKAPK2 or MK2), MAPKAPK3, MAPK-interacting kinase 1 (MNK1), MNK2, p38-activated/regulated protein kinase (PRAK or MAPKAPK5), and mitogen- and stress-activated protein kinase (MSK). PRAK can be activated in response to cellular stress and proinflammatory cytokines. T182 within the activation loop of PRAK has been determined to be the regulatory phosphorylation site. PRAK has been reoprted to be essential for ras-induced senescence and tumor suppression. PRAK mediates senescence upon activation by p38 in response to oncogenic ras. Mediates stress-induced small heat shock protein 27 phosphorylation.

Product References

1) Sun P. et al., (2007) Cell. 128:295-308. (General)
2) New L. et al., (1998) EMBO J. 17:3372-3384. (General)

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