anti-TAB1, mAb (2D3)

CHF 315.00
In stock
YIF-LF-MA0196100 µlCHF 315.00
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Product Details
Synonyms TAB1; MAP3K7IP1; TAK1-binding Protein 1; TGF-β-activated Kinase 1-binding Protein 1; TGF-β-activated Kinase 1 and MAP3K7-binding Protein 1; Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1
Product Type Monoclonal Antibody
Clone 2D3
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human His-TAB1(1~300) protein purified from E. coli.

Western Blot (1:5,000~10,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG2a Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

TAK1 (transforming growth factor-β-activated kinase 1) is a MAPKKK activated by TGF-β, or the pro-inflammatory cytokines TNF (tumour necrosis factor) and IL-1 (interleukin-1), or bacterial LPS (lipopolysacchar-ide). It plays a key role in switching on several pro-inflammatory signaling pathways, including those that activate the MAPKs (mitogen-activated protein kinases), termed p38α MAPK, JNK1/2 (c-Jun N-terminal kinase 1/2) and ERK1/2 (extracellular-signal-regulated kinase 1/2), as well as the transcription factor NFκB (nuclear factor κB). TAB1 (TAK1-binding protein 1) is one of the regulatory subunits of TAK1 and plays a role as an activator of TAK1 in response to stimulation of ΤGF-β. TAB-1 can also mediate MKK-independent p38 kinase. Recently, induction of p38 autophosphorylation and consequent kinase activation by TAB1 expression in cultured neonatal cardiomyocytes have been reported. May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Product References

1) Sun P. et al., (2007) Cell. 128:295-308. (General)
2) New L. et al., (1998) EMBO J. 17:3372-3384. (General)

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