anti-SHP1, mAb (10F5)

CHF 322.00
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YIF-LF-MA0213100 µlCHF 322.00
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Product Details
Synonyms HCP; PTPN6; PTP-1C; SH-PTP1; EC=; Protein-Tyrosine Phosphatase 1C; Protein-Tyrosine Phosphatase SHP-1; Hematopoietic Cell Protein-Tyrosine Phosphatase; Tyrosine-Protein Phosphatase Non-Receptor Type 6
Product Type Monoclonal Antibody
Clone 10F5
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His/ABD-SHP1 protein purified from E. coli.
Application ELISA
Western Blot (1:2,000)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Product Specification Sheet
Datasheet Download PDF
SHP1 and SHP2 represent a subfamily of non-transmembrane protein-tyrosine phosphatases (PTPs) that contain two tandem SH2 (src homology 2) domains. SHPs have two N-terminal SH2 domains (N-SH2 and C-SH2), a classic PTP domain and a C-terminal tail harboring two tyrosyl phosphorylation sites which are phosphorylated differentially by receptor and non-receptor protein-tyrosine kinases (PTKs). Whereas SHP2 is expressed ubiquitously, SHP1 is primarily expressed in hematopoietic cells and behaves as a key regulator controlling intracellular phosphotyrosine levels in lymphocytes. SH2 domains (particularly the N-SH2) also regulate PTP activity. Basal SHP activity is low, but addition of a phosphotyrosyl peptide that binds the N-SH2 (Tyr–P peptide ligand) markedly stimulates catalysis. SHP1 is implicated in signaling from receptor tyrosine kinases (RTKs), cytokine receptors, chemokine receptors and integrins. SHP1-deficient bone marrow macrophages are hyper-adherent to β1- and β2-integrin ligands. Decreased SHP1 level causes abnormal T-lymphocyte proliferation and induces various types of leukemias. Introduction of the SHP1 gene back into a leukemia cell line and a prostate cancer cell line demonstrated the tumor suppressor function of SHP1. Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
Product References
1) Honorat JF et al., (2006) Blood.107(10):4130-4138. (General)
2) Neel BG et al., (2003) Trends Biochem Sci. 28:284-293. (General)
3) Wu C et al.. (2003) Gene. 306:1-12. (General)
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