anti-CREB5, mAb (7D4)

CHF 322.00
In stock
YIF-LF-MA0221100 µlCHF 322.00
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Product Details
Synonyms CREB5; CREBPA; CREB-5; CRE-BPa; cAMP-responsive Element-binding Protein 5; Cyclic AMP-responsive Element-binding Protein 5
Product Type Monoclonal Antibody
Clone 7D4
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human His-CREB5 protein purified from E. coli.

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

CREB (cAMP response element-binding) proteins are transcription factors which bind to certain sequences called cAMP response elements (CRE) in DNA. Transcription factors play a key role in controlling cell proliferation, cell cycle progression, fuel metabolism and so on through changes in target gene transcription. CREB has many functions in many different organs although most of its functions have been studied in relation to the brain. CREB proteins in neurons are thought to be involved in the formation of long-term memories. CRE-BP1 is one of the most abundant CRE-binding proteins. The level of its mRNA is fairly abundant in some regions of the brain such as hippocampus and is induced in the regenerating liver, suggesting that CRE-BP1 is important for both signal transduction in the brain and cellular proliferation. In the majority of patients with acute myeloid leukemia (AML), CREB was found to be overexpressed in the bone marrow and this overexpression was associated with poor prognosis. CREB5 (CRE-Bpa) consists of 508 amino acids and has a molecular weight of 56,840. CREB5 is highly homologous with CRE-BP1 in four regions: two of them are the regions containing the putative metal finger or the DNA-binding domain consisting of the basic amino acid cluster and the leucine zipper. Binds to the cAMP response element and activates transcription.

Product References

1) Siu YT and Jin DY., (2007) FEBS J. 274(13):3224-3232. (General)
2) Nomura N et al., (1993) J Biol Chem. 268(6):4259-4266. (General)

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