anti-α-1 Microglobulin, mAb (10A12)

CHF 322.00
In stock
YIF-LF-MA0226100 µlCHF 322.00
More Information
Product Details
Synonyms HCP; AMBP; Protein HC; α-1 Microglycoprotein; Complex-forming Glycoprotein Heterogeneous in Charge
Product Type Monoclonal Antibody
Properties
Clone 10A12
Isotype Mouse IgG1 κ
Immunogen/Antigen Protein purified from human plasma.
Application

ELISA
Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

α1-microglobulin (protein HC) is a lipocalin with immunosuppressive properties. The lipocalins are a family of proteins which transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. Well known lipocalins are α1-microglobulin, α-1-acid glycoprotein (orosomucoid), apolipoprotein D, β-lactoglobulin, and complement component C8 γ chain etc. A gene in the lipocalin cluster encodes α1-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the α1-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. α1-microglobulin, is a monomeric protein of a molecular size of 27 kDa. It is produced by the liver and circulates in a free form, but is also bound in complexes to high molecular weight molecules. In human plasma, approx. 50% of α1-microglobulin forms a one-to-one complex with monomeric immunoglobulin A (IgA) by a reduction resistant bond. Normal urine contains very small amounts of α1-microglobulin. In conditions with disturbed tubular function, reabsorption of α1-microglobulin is reduced and increased amounts are found in urine. Urinary α1-microglobulin seems a promising marker for renal abnormalities and for the differentiation of various nephrological and urological pathologies. Inter-α-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.

Product References

1) Penders J and Delanghe JR, (2004) Clin Chim Acta. 346(2):107-118. (General)
2) Bo Akerstrom et al., (2000) Biochim Biophys Acta. 1482(1-2):172-184. (General)
3) Xu S and Venge P, (2000) Biochim Biophys Acta. 1482(1-2):298-307. (General)

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