anti-Troponin I, mAb (3D10)

CHF 322.00
In stock
YIF-LF-MA0229100 µlCHF 322.00
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Product Details
Synonyms TNNI3; TNNC1; Cardiac Troponin I; Troponin I; Cardiac Muscle
Product Type Monoclonal Antibody
Clone 3D10
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His-Troponin I (partial) protein purified from E. coli.
Application ELISA
Western Blot (1:2,000)
Immunoprecipitation (2 μl)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Product Specification Sheet
Datasheet Download PDF
Troponin complex consists of three components, troponin I, T and C. The complex along with tropomyosin is located on the actin filament and is essential for the calcium-mediated regulation of skeletal and cardiac muscle contraction. Three isoforms of troponin I have been described for striated muscle. Two isoforms are characteristic for fast and slow skeletal fibers and one isoform for cardiac muscle. Troponin I consists of 181-211 amino acid residues, and the cardiac isoform is larger due to the presence of an additional N-terminal peptide which has a biologically important function in the interactions of troponin I and troponin C. The main function of troponin I is the inhibition of actomyosin ATPase activity. Cardiac troponin I and T are sensitive biomarkers of myocardial injury and have become central to the diagnosis of myocardial infarction. They are elevated in many clinical syndromes associated with direct myocardial injury, myocardial ischemia, or ventricular strain. They are also released in a number of clinical situations in which thrombotic complications of coronary artery disease. These situations include conditions like pulmonary embolism, sepsis, myocarditis, and acute stroke. Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Product References
1) Fromm RE Jr et al., (2007) Crit Care Med. 35(2):584-588. (General)
2) Babuin L and Jaffe AS, (2005) CMAJ. 173(10):1191-1202. (General)
3) Hunkeler NM et al., (1991) Circ. Res. 69;1409-1414. (General)
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