anti-Syk, mAb (12E3)

CHF 315.00
In stock
YIF-LF-MA0239100 µlCHF 315.00
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Product Details
Synonyms SYK; p72-Syk; EC=; Spleen Tyrosine Kinase; Tyrosine-Protein Kinase SYK
Product Type Monoclonal Antibody
Clone 12E3
Isotype Mouse IgG2b κ
Immunogen/Antigen Synthetic peptide.

Western Blot (1:1,000)
Immunoprecipitation (2 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG2b Isotype Control

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Syk, Spleen tyrosine kinase, is expressed in a wide range of hematopoietic and non-hematopoietic cells and plays a key role in adaptive immune system, which is the immunoreceptor (B cell receptor and Fc-receptors) signaling pathways including Fcγ receptor-mediated phagocytosis. In hematopoietic cells such as B and T lymphocytes, natural killer cells, mast cells, macrophages and platelets, Syk is involved in the proximal signaling downstream of activated immunoreceptors (e.g. BCR, TCR, Fc receptors) containing immunoreceptor tyrosine-based activation motifs (ITAMs) to which it binds using its tandem SH2 domains. Activated and autophosphorylated Syk then phosphorylates its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis. Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-γ-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion

Product References

1) Turner M, et al, Immunol Today. 2000; vol.21(3):148-154. (General)
2) Berton G, et al, Trends Immunol. 2005; vol.26(4):208-214. (General)
3) Coopman PJ, Mueller SC. Cancer Lett. 2006; vol.241(2):159-173. (General)
4) Navara CS Curr Pharm Des. 2004; vol.10(15):1739-1744. (General)

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