anti-R-Ras, mAb (6A8)

CHF 322.00
In stock
YIF-LF-MA0251100 µlCHF 322.00
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Product Details
Synonyms p23; RRAS; Ras-related Protein R-Ras
Product Type Monoclonal Antibody
Properties
Clone 6A8
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His-R-Ras protein purified from E. coli.
Application

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

The Ras superfamily of small GTPases includes the Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signal pathways control such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. These GTPases function as molecular switches that control eukaryotic cell function by cycling between two interconvertible forms, a GDP-bound inactive form and a GTP-bound active form. The binding of GTP leads to a conformational change in the downstream effector-binding domain of the G-protein. The small GTPases are monomeric G-proteins with molecular masses over the range 20–30 kDa. Ras is attached to the cell membrane by prenylation. Mutations in the Ras family of proto-oncogenes (comprising H-Ras, N-Ras and K-Ras) are very common, being found in 20% to 30% of all human tumours. The frequency of RAS mutations is among the highest for any gene in human cancer. K-ras mutations occur frequently in non-small-cell lung, colorectal, and pancreatic carcinomas; H-ras mutations are common in bladder, kidney, and thyroid carcinomas; N-ras mutations are found in melanoma, hepatocellular carcinoma, and hematologic malignancies. Regulates the organization of the actin cytoskeleton.

Product References

1) Bhattacharya M et al. (2004) Biochem Soc Trans. 32(Pt 6):1040-1044. (General)
2) Adjei AA, (2001) J Natl Cancer Inst. 93(14):1062-1074. (General)
3) Reuter CW et al. (2000) Blood. 96(5):1655-1669. (General)

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