anti-RSK2/3, mAb (3C1)

CHF 322.00
In stock
YIF-LF-MA0252100 µlCHF 322.00
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Product Details
Synonyms ISPK1; RSK-2; ISPK-1; p90RSK3; RPS6KA3; pp90RSK2; p90-RSK 3; MAPKAPK-1b; EC=2.7.11.1; S6K-α-3; MAPKAP Kinase 1b; Ribosomal S6 Kinase 2; MAPK-activated Protein Kinase 1b
Product Type Monoclonal Antibody
Properties
Clone 3C1
Isotype Mouse IgG2b κ
Immunogen/Antigen Recombinant human His/ABD-RSK3 (aa 415-733) protein purified from E. coli.
Application

ELISA
Western Blot (1:1,000~2,000)

Crossreactivity Human
Mouse
Rat
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threonine kinases that lie at the terminus of the ERK pathway. In humans, the RSK family consists of four isoforms (RSK1 to -4). RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, both of which are catalytically functional. Theses kinase dimains are activated in a sequential manner by a series of phosphorylations. RSK regulates gene expression via association and phosphorylation of transcriptional regulators including c-Fos, estrogen receptor, NFκB/IκB α, cAMP-response element-binding protein (CREB). ERK activates the C-terminal kinase of RSK, leading to activation of the N-terminal kinase. Members of the RSK family are present in the cytoplasm as well as the nucleus. Addition of growth factor to the cells results in the activation of both cytosolic and nuclear RSK and the translocation of the cytosolic RSK into the nucleus upon activation. The activation and nuclear translocation of RSK result in phosphorylation and activation of transcription factors. Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

Product References

1) Roux, P. P. et al., (2003) Mol Cell Biol. 23: 4796–4804. (General)
2) Frodin, M. and Gammeltoft ,S., (1999) Mol Cell Endocrinol. 151:65-77. (General)
3) Fisher, T. L. and Blenis, J., (1996) Mol. Cell. Biol. 16:1212-1219. (General)

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