anti-DUSP3/VHR, mAb (ARM-1)

CHF 315.00
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YIF-LF-MA0253100 µlCHF 315.00
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Product Details
Synonyms VHR; DUSP3; EC=; EC=; Vaccinia H1-related Phosphatase; Dual Specificity Protein Phosphatase 3; Dual Specificity Protein Phosphatase VHR
Product Type Monoclonal Antibody
Clone ARM-1
Isotype Mouse IgG1 κ
Immunogen/Antigen Recombinant human protein purified from E. coli.

Western Blot (1:2,000)
Immunoprecipitation (1 μl)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signaling molecules, such as the MAP kinase family. Recently, increasing attention has been focused on the growing family of PTPs. Like PTKs, PTPs have been implicated in cell signaling, cell growth and proliferation, and oncogenic transformation. Moreover, some PTPs can be involved in cell cycle regulation and embryogenesis. Dual specificity phosphatases (DSPs) are an emerging subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which appears to be selective for dephosphorylating the critical phosphothreonine and phosphotyrosine residues. The prototypical DSP is the VH1 gene in vaccinia virus expressed in late-stage viral infection. A shallow active site pocket in VHR allows for the hydrolysis of phosphorylated serine, threonine, or tyrosine protein residues, whereas the deeper active site of protein tyrosine phosphatases (PTPs) restricts substrate specificity to only phosphotyrosine. This protein shows activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate.

Product References

1) Tabernero L et al. (2008) FEBS J. 275(5):867-882 (General)
2) Yuvaniyama J et al. (1996) Science 272:1328-1331. (General)
3) Ishibashi T et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89:12170-12174. (General)

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