anti-CAD (Caspase-activated Dnase), mAb (4B8)

CHF 322.00
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YIF-LF-MA0255100 µlCHF 322.00
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Product Details
Synonyms CAD; DFFB; CPAN; DFF-40; Caspase-activated DNase; Caspase-activated Nuclease; Caspase-activated Deoxyribonuclease; DNA Fragmentation Factor Subunit β; DNA Fragmentation Factor 40 kDa Subunit
Product Type Monoclonal Antibody
Clone 4B8
Isotype Mouse IgG2a κ
Immunogen/Antigen Recombinant human His-CAD protein purified from E. coli.
Application ELISA
Western Blot (1:1,000)
Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Product Specification Sheet
Datasheet Download PDF
Caspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. Cancer which is a cell death process removing toxic and/or useless cells during mammalian development can be induced by a variety of stimuli, including the death factors of the tumor necrosis factor family, or UV irradiation, anticancer drugs, and survival factor deprivation. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. CAD, which can be activated by caspases, exists as a complex with its inhibitor, inhibitor of CAD (ICAD). ICAD helps correct folding of CAD and remains complexed with CAD to inhibit the DNase activity of CAD. Caspase, which is activated during the apoptotic process, cleaves ICAD, and the CAD released from ICAD enters the nuclei to cleave the chromosomal DNA. Internal as well as external signals can activate caspases and this is under the control of the balance between pro-and anti-apoptotic proteins of the Bcl-2 family, heat shock proteins, and inhibitors of apoptosis proteins (IAPs). Currently, fourteen members of the caspase family have been identified, of which seven mediate apoptosis. Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Product References
1) Vermeulen K et al. (2005) Ann Hematol. 84(10):627-39. (General)
2) Mukae N et al. (1998) Proc. Natl. Acad. Sci. U.S.A. 95:9123-9128. (General)
3) Enari M et al. (1998) Nature 391:43-50. (General)
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