anti-Thyroglobulin, mAb (7C2)

CHF 322.00
In stock
YIF-LF-MA0268100 µlCHF 322.00
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Product Details
Synonyms Tg; TG; Thyroglobulin
Product Type Monoclonal Antibody
Properties
Clone 7C2
Isotype Mouse IgG1 κ
Immunogen/Antigen Human protein.
Application

Western Blot (1:1,000)

Crossreactivity Human
Purity Detail Ammonium sulfate precipitation.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Thyroglobulin (Tg) is a 660 kDa, dimeric protein consisting of two subunits containing 2750 amino acids with a molecular weight of 330 kDa. Among twenty putative N-linked glycosylation sites, only 16 are glycosylated in the mature protein. Tg is produced by and used entirely within the thyroid gland. Tg is the precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Iodinated Tg is stored in the lumen of thyroid follicles. Upon stimulation by thyroid stimulating hormone (TSH), Tg is reabsorbed into thyrocytes and degraded to end product T3 and T4 that are subsequently secreted into the bloodstream. Tg-specific antibodies help in the diagnosis of with Hashimoto's thyroiditis which is an autoimmune disease inducing hypothyroidism, or Graves‘ disease which is a thyroid disorder characterized by goitre, exophthalmos, and hyperthyroidism. Thyroid carcinoma developing from dyshormonogenic goiters due to Tg mutation have been reported. It has been suggested that constant and prolonged stimulation by TSH might result in the appearance of thyroid carcinoma. Tg levels in the blood can be used as a tumor marker for papillary and follicular thyroid cancer. Tg levels in the blood can also be elevated in cases of Graves' disease. TSH (Thyroid-stimulating hormone)-stimulated Tg test using a Tg cutoff of 2 μ g/liter is sufficiently sensitive to be used as the principal test in the follow-up management of low-risk patients with DTC (differentiated thyroid cancer). Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

Product References

1) Lin JD, (2008) Clin Chim Acta. 388(1-2):15-21. (General)
2) Gupta M and Chia SY, (2007) Curr Opin Endocrinol Diabetes Obes. 14(5):383-388. (General)
3) Mazzaferri EL et al. (2003) J Clin Endocrinol Metab. 88(4):1433-1441. (General)

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